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US 2003/0143195 A1Published application
Use of histamine as a drug delivery enhancing compound for use in transmucosal or transdermal delivery
OwnerJudy Senior Pinskerinventor
Life of this patent
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Abstract
A transmucosally administerable composition with enhanced penetration comprising: about 0.001% to about 2.5% of a delivery agent selected from the group consisting of histamine, histamine dihydrochloride, histamine phosphate, a pharmaceutically acceptable salt thereof, other histamine-receptor agonists, about 0.2% to about 75% of a pharmaceutically active medicament, about 0% to about 99.8% of solvent, and about 0% to about 15% of a gelling agent.
Claims17
A transmucosally administrable composition comprising:
- a pharmaceutically active compound;
- and
- a permeation enhancing agent, wherein said agent is selected from the group consisting of histamine, histamine dihydrochloride, histamine phosphate, a pharmaceutically acceptable salt thereof, and other histamine agonists.
A method of manufacture of a pharmaceutical composition for administration to the buccal mucosa comprising:
- providing a therapeutic compound and a permeation enhancing agent selected from the group consisting of histamine, histamine dihydrochloride, histamine phosphate, histamine agonists, and histamine salts in a pharmaceutically acceptable form;
- and
- incorporating said therapeutic compound and said permeation enhancing agent into a transmucosal delivery system.
Dependencies are inferred from the claim text.