Chemokine beta-1 fusion proteins
OwnerAdam Bell, Steven M. Rubeninventors
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Abstract
The present invention relates to novel chemokine polypeptides and encoding nucleic acids. More specifically, therapeutic compositions and methods are provided using isolated nucleic acid molecules encoding a human chemokine beta-1 (Ckβ-1 or Ckb1) polypeptide (previously termed monocyte-colony inhibitory factor (M-CIF), MIP1-γ, and Hemofiltrate CC chemokine-1 (HCC-1)), and Ckb1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same. Also provided are methods of treating, preventing, ameliorating diseases using such compounds.
Claims17
A Ckb1 protein comprising a deletion in amino acid residues selected from:
- (a) the amino terminus, (b) the carboxy terminus, and (c) the amino terminus and carboxy terminus of the polypeptide shown in FIG. 1 (SEQ ID NO:2).
Dependencies are inferred from the claim text.