Protease enzyme inhibitors
AssigneeThe Procter & Gamble Company
InventorsTodd Laurence Underiner, Renae Dianna Fossum, John McMillan McIver
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Abstract
The present invention relates to compounds having the general formula: [Poly][Brketopenst](L)z—[R—CHO]┐y wherein [Poly] is a water-soluble, non-peptidic polymer component, L is an optionally present linking group, and RCHO is a substrate capable of interacting with one or more protease enzymes to reversibly inhibit said enzyme, and wherein said substrate comprises a peptide or peptide-like aldehyde. The index z is 0 when linking groups are absent and z is 1 when linking groups are present. The index y is at least 1. The inhibitors of the present invention are suitable for use in personal care compositions, inter alia, body washes, shampoos, and skin creams.
Claims32
An enzyme inhibitor conjugate having the formula:
- [Poly][Brketopenst](L)z—[R—CHO]┐y
- [Poly] is a water-soluble, non-peptidic polymer component, L is an optionally present linking group, and RCHO is a substrate capable of interacting with one or more enzymes to reversibly inhibit said enzyme;
- y has the value of at least 1;
- z has the value 0 or 1.
An enzyme inhibitor conjugate having the formula:
- 26
- wherein R4 and R5 are each independently selected from the group consisting of substituted or unsubstituted:
- i) phenyl;
- ii) benzyl;
- iii) naphthyl;
- iv) linear or branched C1-C7 alkyl;
- v) and mixtures thereof;
- n is from 3 to 200.
An enzyme inhibitor conjugate having the formula:
- 27
An enzyme inhibitor conjugate having the formula:
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An enzyme inhibitor conjugate having the formula:
- 29
An enzyme inhibitor conjugate having the formula:
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An enzyme inhibitor conjugate having the formula:
- 31
- wherein R4 is substituted or unsubstituted benzyl, R5 is 1-methylethyl, 1-methylpropyl, 2-methylpropyl, or mixtures thereof;
- n is an integer representing the average molecular weight of an ethyleneoxy unit, said integer selected from the group consisting of 7, 122, 16, 45, and 113.
A composition comprising:
- a) from about 0.001% to about 0.5% by weight, one or more protease enzymes;
- b) from about 0.001% to about 0.5% by weight, one or more enzyme inhibitor conjugate having the formula:
- [Poly][Brketopenst](L)z—[R—CHO]┐y
- [Poly] is a water-soluble, non-peptidic polymer component, L is an optionally present linking group, and RCHO is a substrate capable of interacting with one or more enzymes to reversibly inhibit said enzyme;
- y has the value of at least 1;
- z has the value 0 or 1;
- and
- c) the balance carriers and adjunct ingredients.
Dependencies are inferred from the claim text.