Polymer conjugates of protein kinase C inhibitors
AssigneeShearwater Corporation
InventorsMichael David Bentley, Xuan Zhao
Life of this patent
Estimating the term…
Abstract
The invention provides polymer conjugates of protein kinase C (PKC) inhibitors comprising a polymer, such as poly(ethylene glycol), covalently attached to a PKC inhibitor, such as a bisindolylmaleimide molecule. The linkage between the polymer and the PKC inhibitor is preferably hydrolytically degradable. The invention also includes a pharmaceutical composition comprising a polymer conjugate of a PKC inhibitor and a method of treating any condition responsive to a PKC inhibitor by administering a polymer conjugate of the invention.
Claims25
A polymer conjugate comprising a water soluble and non-peptidic polymer covalently attached to a protein kinase C inhibitor.
A pharmaceutical composition, comprising:
- a polymer conjugate comprising a water soluble and non-peptidic polymer covalently attached to a protein kinase C inhibitor, and
- a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.