Stable polymeric micelle-type drug composition and method for the preparation thereof
AssigneeSamyang Corporation
InventorsMin-Hyo Seo, Yil-Woong Yi, Jae-Won Yu
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Abstract
The invention is directed to a biocompatible stable composition containing a hydrophobic drug, such as paclitaxel. The composition, which forms a syringeable polymeric micellar solution in aqueous or body fluids, is a freeze-dried product comprising a hydrophobic drug, i.e. paclitaxel, and an amphiphilic block copolymer wherein a hydrophobic group having affinity or attraction with the hydrophobic drug, such as paclitaxel, is incorporated on its end. The invention provides a shelf life of longer than three years in a sterilized container, stability of longer than three days in infusion fluid, has minimal side effects and shows improved bioavailability.
Claims23
A composition capable of forming a polymeric micelle in a body fluid or an aqueous medium, said composition comprising an amphiphilic block copolymer having a hydrophilic A block component and a hydrophobic biodegradable B block component, wherein the biodegradable B block component of the copolymer is modified with an end group having attraction to a hydrophobic drug.
Dependencies are inferred from the claim text.