Methods and unit dose formulations for the inhalation administration of aminoglycoside antibiotics
OwnerRobert John Speirs, Barbara Ann Schaeffler +1inventors
InventorsRobert John Speirs, Barbara Ann Schaeffler, Peter Bruce Challoner
Life of this patent
Estimating the term…
Abstract
A patient suffering from an endobronchial infection is treated by administering to the patient for inhalation a dose of less than about 4.0 ml of a nebulized aerosol formulation comprising from about 60 to about 200 mg/ml of an aminoglycoside antibiotic, such as tobramycin, in a physiologically acceptable carrier in a time period of less than about 10 minutes. Unit dose devices for storage and delivery of the aminoglycoside antibiotic formulations are also provided.
Claims17
A method of the treatment of a patient in need of such treatment comprising administering to the patient a dose of 4.0 ml or less of a nebulized aerosol formulation comprising from about 60 to about 200 mg/ml of an aminoglycoside antibiotic in less than 10 minutes.
A unit dose device, comprising a container containing less than about 4.0 ml of an aminoglycoside antibiotic formulation comprising from about 60 to about 200 mg/ml of an aminoglycoside antibiotic in a physiologically acceptable carrier.
A system for delivering an aminoglycoside antibiotic formulation to a patient in need of such treatment, comprising a unit dose device comprising a container containing less than about 4.0 ml of an aminoglycoside antibiotic formulation comprising from about 60 to about 200 mg/ml of an aminoglycoside antibiotic in a physiologically acceptable carrier, and means for delivering the aminoglycoside antibiotic formulation from the unit dose device for inhalation by the patient in aerosolized form in less that 10 about minutes.
Dependencies are inferred from the claim text.