Medicine, carrier for medicine, method of producing medicine, and method of tumor treatment
AssigneeHitachi, Ltd.
InventorsKenichi Kawabata, Shinichiro Umemura, Kazuaki Sasaki
Life of this patent
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Abstract
A medicinal preparation capable of lowering the threshold of cavitation and generating active oxygen species via acoustic cavitation caused by an ultrasound is provided. The preparation, which is to be used in combination with ultrasonic irradiation, comprises a shell within the internal space of which a gas is enclosed and which contains or retains a substance capable of generating active oxygen species upon ultrasonic irradiation of the shell.
Claims11
A medicinal preparation which comprises a shell with a gas enclosed in the internal space thereof as well as a substance capable of generating active oxygen species upon irradiation of the shell with an ultrasound as retained or contained in the shell.
A carrier for carrying a medicinal component and to be used in combination with ultrasonic irradiation, wherein the carrier has a shell with an outside diameter of not smaller than 0.1 μm but not greater than 5 μm with a gas being enclosed within the inside thereof in a gaseous condition.
A method of producing medicinal preparations to be used in combination with ultrasonic irradiation comprising the steps of:
- forming foams or bubbles by irradiating a solution containing a surface active protein and a substance capable of generating active oxygen species upon ultrasonic irradiation;
- and
- selecting bubbles within a desired range of size from among the bubbles formed.
A tumor treatment method comprising the step of:
- administering, to a patient, a medicinal preparation comprising a shell not smaller than 0.1 μm but not greater than 5 μm in outside diameter with a gas enclosed within the inside and a substance capable of generating active oxygen species upon irradiation of the shell with an ultrasound;
- and
- irradiating the affected site of the patient with an ultrasound at a fundamental frequency and an ultrasound at the second-harmonic frequency relative to the fundamental ultrasound in the manner of superposition on each other.
Dependencies are inferred from the claim text.