Device for chemical and biochemical reactions using photo-generated reagents
AssigneeThe Regents of the University of Michigan
InventorsXiaolian Gao, Xiaochuan Zhou, Erdogan Gulari
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Abstract
This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. Specifically, the method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.
Claims27
A device for selectively converting photogenerated reagent precursors to photogenerated reagents comprising:
- a) a substrate comprising at least one solid surface containing a plurality of spatially separated reaction sites;
- and
- b) an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator to form an irradiation pattern, wherein said optical system selectively irradiates a plurality of reaction sites.
A device for selectively converting photogenerated reagent precursors to photogenerated reagents for effecting a chemical reaction comprising:
- a) a substrate comprising at least one solid surface containing a plurality of spatially separated reaction sites, wherein said reaction sites comprise one or more reagents and contain a solution of at least one photogenerated reagent precursor;
- and
- b) an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator to form an irradiation pattern, which optical system selectively irradiates a plurality of reaction sites thereby converting the photogenerated reagent precursors to photogenerated reagents thereby effecting a chemical reaction.
A device for selectively converting photogenerated reagent precursors to photogenerated reagents for effecting deprotection of one or more initiating moieties comprising:
- a) a substrate comprising at least one solid surface containing a plurality of spatially separated reaction sites, wherein said reaction sites comprise one or more initiating moieties and contain a solution of at least one photogenerated reagent precursor;
- and
- b) an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator to form an irradiation pattern, wherein said optical system selectively irradiates a plurality of reaction sites whereby said initiating moieties are deprotected by conversion of said photogenerated reagent precursors to photogenerated reagents.
Dependencies are inferred from the claim text.