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AssigneeBristol-Myers Squibb Company
InventorsJoseph Nolfo, Maxine Soumellant, Victor W. Rosso, Peter Lee, Mayra B. Reyes, John J. Venit
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Multiple parallel chemical reactions are performed under pressure in a reactor including a multi-row array of reaction vessels situated between a temperature control base and a fluid flow manifold. The manifold consists of an input portion connected to the fluid supply by a five-way valve and a distribution portion which includes separate parallel distribution channels, one for each row of reaction vessels. A control valve for each distribution channel is interposed between the manifold portions such that the fluid flow to each row of reaction vessels can be independently controlled. An explosion proof transparent shield can be situated between the base and manifold, surrounding the reaction vessels. The interior of the shield can be flooded with inert gas.
Apparatus for performing parallel chemical reactions under pressure in a plurality of reaction vessels, said apparatus comprising a base with first and second sets of reaction vessel receiving recesses into which reaction vessels are adapted to be received, at least one of said recess sets comprising more than one recess, fluid supply means, fluid manifold means, means operably connecting said fluid supply means and said manifold means, said manifold means comprising first and second valve means independently operably connecting said fluid supply means to each of said reaction vessels received in each of said first and second sets of reaction vessel receiving recesses, respectively.
Apparatus for performing parallel chemical reactions under pressure in a plurality of reaction vessels, said apparatus comprising a base with an array of reaction vessel receiving recesses into which reaction vessels are adapted to be received, fluid supply means, fluid manifold means comprising an input manifold, a distribution manifold and valve means interposed between said manifolds, means operably connecting said fluid supply means and said input manifold such that fluid from said supply means passes through said input manifold, said valve means and said distribution manifold, to said reaction vessels.
Apparatus for performing parallel chemical reactions under pressure in a plurality of reaction vessels, said apparatus comprising a base with first and second rows of reaction vessel receiving recesses into which reaction vessels are adapted to be received, at least one of said rows comprising more than one recess, fluid supply means, fluid manifold means, means operably connecting said fluid supply means and said manifold means, said manifold means comprising first and second valve means independently operably connecting said fluid supply means to each of said reaction vessels received in each of said first and second rows of reaction vessel receiving recesses, respectively.
A tool for use in combination with apparatus for performing parallel chemical reactions under pressure in first and second reaction vessels, said apparatus comprising fluid supply means, fluid distribution means operably connecting said fluid supply means and said first and second reaction vessels, said fluid distribution means comprising a surface, a fluid channel having an internally threaded portion proximate said surface, a nozzle comprising an externally threaded hollow cylindrical portion adapted to be rotatably received within said channel portion and a hollow head portion comprising a shoulder, an o-ring received around said cylindrical portion, between said surface and said shoulder, when said cylindrical nozzle portion is received within said channel portion and wherein said tool comprises a rotatable handle and means attached to said handle for engaging said head until said nozzle is rotated to a position wherein said shoulder is spaced from said surface a predetermined distance, such that said o-ring is compressed to the desired degree.
Apparatus for performing parallel chemical reactions under pressure in a plurality of reaction vessels containing a liquid reaction mixture, for use in combination with magnetic stirrer means, said apparatus comprising a base with a vessel receiving recesses into which reaction vessels of a given diameter are adapted to be received, fluid supply means, fluid manifold means for operably connecting said fluid supply means with the reaction vessels, a stir bar situated in one of said reaction vessels, said stir bar being longer than said given reaction vessel diameter, such that it extends through the surface of said liquid reaction mixture.
Dependencies are inferred from the claim text.