Methods and sterilizing biological materials
OwnerRandall S. Kent, Edward A. Hortoninventors
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Abstract
Methods are disclosed for sterilizing biological products to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas and parasites.
Claims58
A method for sterilizing a biological material that is sensitive to ionizing radiation, said method comprising:
- (i) reducing the residual solvent content of a biological material to a level effective to protect said biological material from said ionizing radiation;
- and
- (ii) irradiating said biological material with a suitable ionizing radiation at an effective rate for a time effective to sterilize said biological material.
A method for sterilizing a biological material that is sensitive to ionizing radiation, said method comprising:
- (i) adding to a biological material at least one stabilizer in an amount effective to protect said biological material from said ionizing radiation;
- and
- (ii) irradiating said biological material with a suitable ionizing radiation at an effective rate for a time effective to sterilize said biological material.
A method for sterilizing a biological material that is sensitive to ionizing radiation, said method comprising:
- (i) adding to a biological material at least one stabilizer in an amount effective to protect said biological material from said ionizing radiation;
- and
- (ii) irradiating said biological material with a suitable ionizing radiation at a low rate for a time effective to sterilize said biological material.
A method for sterilizing a biological material that is sensitive to ionizing radiation, said method comprising:
- (i) reducing the residual solvent content of a biological material to a level effective to protect said biological material from said ionizing radiation;
- and
- (ii) irradiating said biological material with a suitable ionizing radiation at a low rate for a time effective to sterilize said biological material.
A method for sterilizing a biological material that is sensitive to ionizing radiation, said method comprising:
- (i) reducing the residual solvent content of a biological material to a level effective to protect said biological material from said ionizing radiation;
- (ii) adding to said biological material at least one stabilizer in an amount effective to protect said biological material from said ionizing radiation;
- and
- (iii) irradiating said biological material with a suitable ionizing radiation at an effective rate for a time effective to sterilize said biological material, wherein steps (i) and (ii) may be performed in inverse order.
The method according to claims 1-10, wherein said biological material is suspended in an organic solvent following reduction of said residual solvent content.
Dependencies are inferred from the claim text.