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OwnerFrank Corbin III, Dennis Hlavinka +2inventors
InventorsFrank Corbin III, Dennis Hlavinka, Laura Goodrich, Raymond P. Goodrich
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Methods for decontaminating fluids such as blood products, particularly platelets or red blood cells, are provided. The methods include mixing substantially non-toxic amounts of an endogenous photosensitizer such as riboflavin, or an endogenously-based derivative photosensitizer, with the fluid, increasing the dissolved oxygen content of the fluid to an amount sufficient to enhance a reaction of the photosensitizer in which singlet oxygen is formed and reduce competing reactions; and exposing the fluid to visible light photoradiation to activate the photosensitizer and substantially inactivate the pathogens. Blood products produced by the method, and systems for carrying out the method are also provided.
A method for treating a fluid to inactivate pathogens which may be present therein, comprising:
31 The method of claim 1 wherein said pathogens are selected from the group consisting of extracellular and intracellular viruses, bacteria, bacteriophages, fungi, blood-transmitted parasites, and protozoa, and mixtures of any two or more of the foregoing.
The method of claim 31 wherein said viruses are selected from the group consisting of acquired immunodeficiency (HIV) virus, hepatitis A, B and C viruses, sindbis virus, cytomegalovirus, vesicular stomatitis virus, herpes simplex viruses, e.g. types I and II, human T-lymphotropic retroviruses, HTLV-III, lymphadenopathy virus LAV/IDAV, parvovirus, transfusion-transmitted (TT) virus, and Epstein-Barr virus, bovine viral diarrhea virus, pseudorabies, and mixtures of any two or more of the foregoing.
The method of claim 31 wherein said bacteriophages are selected from the group consisting of ΦX174, Φ6, λ, R17, T4, and T2, and mixtures of any two or more of the foregoing.
The method of claim 31 wherein said bacteria are selected from the group consisting of P. aeruginosa, S. aureus, S. epidermidis, E. coli, K. pneumoniae, E. faecalis, B. subtilis, S. pneumoniae, S. pyrogenes, S. viridans, B. cereus, E. aerogenes, propionabacter, C. perfringes, E. cloacae, P. mirabilis, S. cholerasuis, S. liquifaciens, S. mitis, Y entercolitica, P. fluorescens, S. enteritidis, C. freundii, and S. marcescens, and mixtures of any two or more of the foregoing.
A method for treating platelets to inactivate pathogens which may be present therein, comprising:
A biological composition comprising:
A decontamination system for a fluid comprising:
A method of making a decontamination system comprising:
A method of decontaminating a fluid comprising:
A method of increasing the storage life of photochemically decontaminated platelets platelets comprising:
Dependencies are inferred from the claim text.