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US 2003/0126628 A1Published application
Ovomucoid promoter and methods of use
AssigneeAviGenics, Inc.
InventorsAlex J. Harvey, Youliang Wang
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AssigneeAviGenics, Inc.
InventorsAlex J. Harvey, Youliang Wang
Estimating the term…
The present invention provides novel isolated nucleic acids comprising an avian nucleic acid sequence encoding an ovomucoid gene expression control region. The ovomucoid promoter region of the present invention allows expression of an operably linked heterologous nucleic acid insert in a transfected cell such as, for example, an avian oviduct cell. The isolated avian ovomucoid promoter of the present invention may be operably linked with a selected nucleic acid insert, wherein the nucleic acid insert encodes a polypeptide desired to be expressed in a transfected cell. The recombinant DNA of the present invention may further comprise a polyadenylation signal sequence. The present invention further includes expression vectors comprising an isolated avian ovomucoid gene expression control region of the present invention, and transfected cells and transgenic avians comprising the expression vectors.
An isolated nucleic acid comprising an isolated avian ovomucoid gene expression control region comprising the nucleic acid sequence in SEQ ID NO:
A recombinant DNA molecule comprising an isolated avian ovomucoid gene expression control region operably linked to a nucleic acid insert encoding a polypeptide.
An expression vector that integrates into a host cell and comprising an isolated avian ovomucoid gene expression control region operably linked to a nucleic acid insert encoding a polypeptide, wherein the expression control region directs production of a transcript.
A method of expressing a heterologous polypeptide in a host cell, comprising the steps of:
A transgenic avian having a heterologous polynucleotide sequence comprising a nucleic acid insert encoding the heterologous polypeptide and operably linked to an avian ovomucoid gene expression control region.
An isolated nucleic acid having a codon complement optimized for protein expression in an avian.
Dependencies are inferred from the claim text.