Carrier and kit for intraluminal delivery of active principles or agents
OwnerFranco Vallana, Maria Curcio +3inventors
InventorsFranco Vallana, Maria Curcio, Maria Cristina Cassullo, Andrea Grignani, Andrea Bottelli
Life of this patent
Estimating the term…
Abstract
A carrier for delivering at least one active principle at an intraluminal site. The carrier includes a carrier body, such as a stent. The carrier body is provided with one or more reservoirs. The reservoirs contain nanoparticles which convey at least one active principle. The nanoparticles also comprise a substance having characteristics of preferential affinity attraction to a desired region at the intraluminal site. The nanoparticles can migrate toward the preferred region.
Claims81
A carrier for delivering at least one active principle at an intraluminal site, the intraluminal site having at least a first region and a second region, the carrier comprising:
- a carrier body sized to be conveyed to the intraluminal site, the carrier body having at least one reservoir;
- and
- a plurality of nanoparticles contained within the at least one reservoir, each nanoparticle including an outer envelope and containing the active principle, the outer envelope comprising at least a first substance having characteristics of affinity of preferential attraction to the second region as compared to the first region.
The carrier of claim 3 wherein the core comprises the active principle.
A stent for delivering at least one active principle at an intraluminal site, the intraluminal site having at least a first region and a second region, the stent comprising:
- a body configured to be expandable from a delivery configuration to a deployed configuration, the body being sized to be delivered to the intraluminal site in the delivery configuration, the body having an interior surface and an exterior surface and having at least one reservoir on the exterior surface;
- and
- a plurality of nanoparticles contained within the at least one reservoir, each nanoparticle including an outer envelope and containing the active principle, the outer envelope comprising at least a first substance having characteristics of affinity of preferential attraction to the second region as compared to the first region.
A method for delivering at least one active principle at an intraluminal site, the intraluminal site having at least a first region and a second region, the method comprising:
- providing a stent having a body configured to be expandable from a delivery configuration to a deployed configuration, the body having an interior surface and an exterior surface and having at least one reservoir on the exterior surface;
- placing in the at least one reservoir a plurality of nanoparticles, each nanoparticle including an outer envelope and containing the active principle, the outer envelope comprising at least a first substance having characteristics of affinity of preferential attraction to the second region as compared to the first region;
- delivering the stent in its delivery configuration to the intraluminal site;
- and
- expanding the stent to its deployed configuration at the intraluminal site.
A kit for delivering at least one active principle at a treatment site within the lumen of a vessel, the site having at least a first region and a second region, the kit comprising:
- a carrier body sized to be conveyed through the lumen of the vessel to the treatment site, the carrier body having at least one reservoir;
- a plurality of nanoparticles contained within the at least one reservoir, each nanoparticle including an outer envelope and containing the active principle, the outer envelope comprising at least a first substance having characteristics of affinity of preferential attraction to the second region as compared to the first region;
- and
- a delivery device for advancing the carrier body through the lumen to the treatment site.
A carrier for delivering at least one active principle at an intraluminal site, the intraluminal site having at least a first region and a second region, the carrier comprising:
- a carrier body sized to be conveyed to the intraluminal site, the carrier body having a plurality reservoirs;
- and
- at least two different species of nanoparticles contained within the plurality of reservoirs, each nanoparticle including an outer envelope and containing the active principle, the outer envelope comprising at least a first substance having characteristics of affinity of preferential attraction to the second region as compared to the first region, and the at least two different species of nanoparticles being differentiated from one another by at least one characteristic of the active principle or of the first substance.
A stent for delivering at least one active principle at an intraluminal site, the intraluminal site having at least a first region and a second region, the stent comprising:
- a body configured to be expandable from a delivery configuration to a deployed configuration, the body being sized to be delivered to the intraluminal site in the delivery configuration, the body having an interior surface and an exterior surface and having a plurality of reservoirs on the exterior surface;
- and
- at least two different species of nanoparticles contained within the plurality of reservoirs, each nanoparticle including an outer envelope and containing the active principle, the outer envelope comprising at least a first substance having characteristics of affinity of preferential attraction to the second region as compared to the first region, and the at least two different species of nanoparticles being differentiated from one another by at least one characteristic of the active principle or of the first substance.
A method for delivering at least one active principle at an intraluminal site, the intraluminal site having at least a first region and a second region, the method comprising:
- providing a stent having a body configured to be expandable from a delivery configuration to a deployed configuration, the body having an interior surface and an exterior surface and having a plurality of reservoirs on the exterior surface;
- placing in the plurality of reservoirs at least two different species of nanoparticles, each nanoparticle including an outer envelope and containing the active principle, the outer envelope comprising at least a first substance having characteristics of affinity of preferential attraction to the second region as compared to the first region, and the at least two different species being differentiated from one another by at least one characteristic of the active principle or of the first substance. the;
- delivering the stent in its delivery configuration to the intraluminal site;
- and
- expanding the stent to its deployed configuration at the intraluminal site.
A kit for delivering at least one active principle at a treatment site within the lumen of a vessel, the site having at least a first region and a second region, the kit comprising:
- a carrier body sized to be conveyed through the lumen of the vessel to the treatment site, the carrier body having a plurality of reservoirs;
- at least two different species of nanoparticles contained within the plurality of reservoirs, each nanoparticle including an outer envelope and containing the active principle, the outer envelope comprising at least a first substance having characteristics of affinity of preferential attraction to the second region as compared to the first region, and the two different species being differentiated from one another by at least one characteristic of the active principle or of the first substance;
- and
- a delivery device for advancing the carrier body through the lumen to the treatment site.
Dependencies are inferred from the claim text.