Hemo-and biocompatible beaded polymeric material for purification of physiological fluids of organism, method of producing the material, as well as method of and device for purification of physiological fluids of organism with use of the material

A hemo- and bio compatible beaded adsorbing material as defined in claim 7, wherein the areas of the core surface of the core exposed between portions of the hemo-and biocompatible hydrophillic coating for the physiological fluid which is blood each have the size greater than 10 nm.

A method of producing a hemo- and biocompatible polymeric adsorbing material for purification of physiological fluids of organism, comprising the steps of forming cores of beads having hydrophobic core surface;

• coating the core surface of the beads with a hemo- and biocompatible hydrophillic coating, so that the hemo- and biocompatible coating is applied non-continuously so as to leave on the core surface of the core areas which are not covered with the hemo- and biocompatible coating and therefore remain hydrophobic, and forming the areas with a size which is substantially smaller than a size of an individual cell of the physiological fluid, so that when the physiological fluid passes through the material the individual cell of the physiological fluid can substantially be in contact only with the hemo-and biocompatible coating and can not contact the hydrophobic core surface of the core because the corresponding areas of the core surface which are exposed between parts of the hemo-and biocompatible hydrophilic coating have a smaller size than the individual cell of the physiological fluid.

A method as defined in claim 17, wherein said forming includes forming the areas of the core surface of the core exposed between portions of the hemo-and biocompatible hydrophillic coating for the physiological fluid which is blood each have the size greater than 10 nm.

A method of purification of physiological fluids of organism, comprising the steps of passing a physiological fluid of organism through a hemo-and bio compatible beaded polymeric adsorbing material which has a plurality of beads each having a core with a hydrophobic core surface, and a hydrophilic, hemo-and biocompatible coating applied on the core surface of the core, with the hemo- and biocompatible coating being applied non-continuously so as to leave on the core surface of the core such areas which are not covered with the hemo- and biocompatible coating and therefore remain hydrophobic, and the areas each have a size which is substantially smaller than a size of an individual cell of the physiological fluid, so that when the physiological fluid passes through the material the individual cell of the physiological fluid can substantially be in contact only with the hemo-and biocompatible coating and can not contact the hydrophobic core surface of the core because the corresponding areas of the core surface which are exposed between parts of the hemo-and biocompatible hydrophilic coating have a smaller size than the individual cell of the physiological fluid.

A device for purification of physiological fluids of organism, comprising a container having inlet means, outlet means and an interior;

• and a body of a hemo-and bio compatible beaded polymeric adsorbing material which has a plurality of beads each having a core with a hydrophobic core surface, and a hydrophilic, hemo-and biocompatible coating applied on the core surface of the core, with the hemo- and biocompatible coating being applied non-continuously so as to leave on the core surface of the core such areas which are not covered with the hemo- and biocompatible coating and therefore remain hydrophobic, and the areas each having a size which is substantially smaller than a size of an individual cell of the physiological fluid, so that when the physiological fluid passes through the material the individual cell of the physiological fluid can substantially be in contact only with the hemo-and biocompatible coating and can not contact the hydrophobic core surface of the core because the corresponding areas of the core surface which are exposed between parts of the hemo-and biocompatible hydrophilic coating have a smaller size than the individual cell of the physiological fluid.