Novel hemopoietin receptor protein, NR10
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsMasatsugu Maeda, Noriko Yaguchi
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Abstract
The inventors succeeded in isolating a novel hemopoietin receptor gene (NR10) using a sequence predicted from the extracted motif conserved in the amino acid sequences of known hemopoietin receptors. It was expected that two forms of NR10 exists, a transmembrane type and soluble form. Expression of the former type was detected in tissues containing hematopoietic cells. Thus, NR10 is a novel hemopoietin receptor molecule implicated in the regulation of the immune system and hematopoiesis in vivo. These novel receptors are useful in screening for novel hematopoietic factors capable of functionally binding to the receptor, or developing medicines to treat diseases related with the immune system or hematopoietic system.
Claims19
An isolated nucleic acid of any one of (a) to (d) below:
- (a) a nucleic acid encoding a protein comprising the amino acid sequence of any one of SEQ ID NOs:2, 4 or 17,
- (b) a nucleic acid comprising a coding region in the nucleotide sequence of any one of SEQ ID NOs:1, 3 or 16,
- (c) a nucleic acid encoding a protein that comprises the amino acid sequence of any one of SEQ ID NOs:2, 4 or 17, in which one or more amino acids are replaced, deleted, inserted and/or added and that is functionally equivalent to the protein comprising the amino acid sequence of any one of SEQ ID NOs:2, 4 or 17, and
- (d) a nucleic acid that hybridizes under stringent conditions with the nucleic acid comprising the nucleotide sequence of any one of SEQ ID NOs:1, 3 or 16, and that encodes a protein functionally equivalent to the protein comprising the amino acid sequence of any one of SEQ ID NOs:2, 4 or 17.
An isolated nucleic acid encoding the amino acid sequence of any one of SEQ ID NOs:2, 4 or 17 or a fragment thereof.
A polynucleotide that hybridizes with the nucleic acid comprising the nucleotide sequence of any one of SEQ ID NOs:1, 3 or 16 or the complementary strand thereof and that comprises at least 15 nucleotides.
Dependencies are inferred from the claim text.