Fusogenic liposomes
AssigneeThe University of British Columbia
InventorsPieter R. Cullis, Lewis S.L. Choi, Myrna Monck, Austin L. Bailey
Life of this patent
Estimating the term…
Abstract
The present invention relates to liposomes and virosomes and, more particularly, to liposomal and virosomal delivery systems for transporting materials such as drugs, nucleic acids and proteins.
Claims25
A lipopeptide, said lipopeptide comprising a lipid covalently attached to a peptide by means of an amide bond.
A pharmaceutical composition for introducing a therapeutic compound into a cell of a host, comprising:
- a liposome containing a lipopeptide, said lipopeptide comprising a lipid covalently attached to a peptide by means of an amide bond;
- a therapeutic compound contained in said liposome;
- and
- a pharmaceutically acceptable carrier.
A polymer having the general structure:
- [X—Y]n
- in which:
- X is a trifunctional substrate, wherein at least one of the functional groups is a carboxyl group or a protected carboxyl group;
- Y is ethylene glycol;
- and
- n is an integer having a value ranging from 1 to 20.
A polymer having the general structure:
- [X—Y—Z]n
- in which:
- X and Z are independently selected and are trifunctional substrates wherein at least one of the functional groups of each of the trifunctional substrates is a carboxyl group or a protected carboxyl group;
- Y is ethylene glycol;
- and
- n is an integer having a value ranging from 1 to 20.
A pharmaceutical composition for introducing a therapeutic compound into a cell of a host, comprising:
- a liposome containing a pH-sensitive fusogenic polymer, said pH-sensitive fusogenic polymer selected from the group consisting of
- [X—Y]n
- and
- [X—Y—Z]n
- in which:
- X is a trifunctional substrate, wherein at least one of the functional groups is a carboxyl group or a protected carboxyl group;
- Z is a trifunctional substrate, wherein at least one of the functional groups is a carboxyl group or a protected carboxyl group Y is ethylene glycol;
- and
- n is an integer having a value ranging from 1 to 20;
- a therapeutic compound contained in said liposome;
- and
- a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.