5-Aminolevulinic acid formulation dissolved/dispersed in non-aqueous solvents
OwnerBruno Gander, Antje Bunke +1inventors
InventorsBruno Gander, Antje Bunke, Gerd Burmeister
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Abstract
The invention concerns compositions that contain 5-aminolevulinic acid or/and derivatives thereof dissolved or dispersed in a non-aqueous liquid. The invention in particular concerns a two-chamber system which contains compositions of 5-aminolevulinic acid and/or derivatives thereof in which the active substances are located in a non-aqueous phase and which are ready-to-use after mixing with an aqueous phase.
Claims28
Composition, characterized in that
- it contains an active substance selected from 5-aminolevulinic acid (5-ALA) or/and a derivative thereof dissolved or dispersed in a non-aqueous liquid which has a dielectric constant ∈ of less than 80 at 25° C. which acts as stabilizer of 5-aminolevulinic acid (5-ALA) or/and the derivative thereof.
Composition as claimed in one of the previous claims, characterized in that
- the non-aqueous liquid is selected from alcohols, ethers, esters, poly(alkylene glycols), phospholipids, DMSO, N-vinylpyrrolidone, N-N-dimethyl acetamide and mixtures thereof.
Composition as claimed in one of the previous claims, characterized in that
- the non-aqueous liquid is at least partially miscible with water.
Composition as claimed in one of the previous claims, characterized in that
- it additionally contains water.
Composition as claimed in one of the previous claims, characterized in that
- the active substance is present in an amount of 1 to 25% by weight in particular of 1 to 15% by weight relative to the total weight of the composition.
Composition as claimed in one of the previous claims, characterized in that
- it additionally contains auxiliary substances or/and additives that are commonly used in cosmetics or pharmaceuticals.
Composition as claimed in one of the previous claims, characterized in that
- it is present as a solution, suspension, emulsion, microemulsion, gel, ointment, spray, foam, suppository or ovulum.
Composition as claimed in one of the previous claims, characterized in that
- it is in the form of a pharmaceutical preparation.
Composition as claimed in one of the previous claims, characterized in that
- it contains an additional medicinal substance.
Use of a non-aqueous liquid which has a dielectric constant ∈ of less than 80 at 25° C. to stabilize 5-aminolevulinic acid (5-ALA) or/and a derivative thereof, wherein the 5-aminolevulinic acid or/and the derivative thereof is dissolved or dispersed in the non-aqueous liquid.
Dependencies are inferred from the claim text.