Substituted urea retinoid agonists

A compound according to structural formula (I):

• 28
• or a pharmaceutically available salt, solvate or hydrate thereof wherein:
• n is an integer from 0 to 2;
• X is S, O or NR4R5;
• R4 and R5 are independently hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl, or optionally together with the nitrogen atom to which they are attached form a heterocyclyl ring;
• A is aryl or heteroaryl;
• Y is CO2R6, C(O)SR7or C(O)NR8R9;
• R1 and R3 are independently hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, cycloalkyl-alkyl, haloalkyl, heteroaryl, heteroarylalkyl, heteroalkyl, heterocyclyl or heterocyclylalkyl;
• and
• R2 is hydrogen, alkyl, hydroxy or oxo;
• R6 is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl;
• R7 is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl;
• R8 and R9 are independently hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl, or together with the nitrogen atom to which they are attached form a heterocyclyl ring;
• with the proviso that R1 is not hydrogen or alkyl when R3 is hydrogen.