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AssigneePhotogen, Inc.
InventorsH. Craig Dees, Timothy C. Scott, Eric A. Wachter, Walter G. Fisher, John Smolik
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New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.
A medicament for intracorporeal application, the medicament comprising at least one halogenated xanthene as a primary active component, wherein said medicament is useful for high energy phototherapeutic treatment, using applied ionizing radiation, of human and animal tissue.
Use of a halogenated xanthene in the preparation of an intracorporeal medicament for high energy phototherapeutic treatment of human and animal tissue using applied ionizing radiation.
Intracorporeal use of a halogenated xanthene comprising:
A pharmaceutical composition for intracorporeal administration comprising a halogenated xanthene for high energy phototherapeutic treatment using applied ionizing radiation.
A method of treating comprising:
An intracorporeally-applicable medicament comprising at least one halogenated xanthene as a primary active component, wherein such medicament is useful for high energy phototherapeutic treatment, using applied ionizing radiation, of human and animal tissue.
A pharmaceutical composition adapted for intracorporeal administration to obtain a high energy phototherapeutic effect, comprising a dosage unit of a halogenated xanthene and an effective amount of applied ionizing radiation.
Dependencies are inferred from the claim text.