New indenoindolone compounds

A compound selected from those of formula (I):

• 12
• wherein
• R represents:
• hydrogen,
• linear or branched (C1-C6)alkyl optionally substituted by carboxy, by linear or branched (C1-C6)alkoxycarbonyl or by NR10R11 (wherein R10 and R11, which may be identical or different, each represents linear or branched (C1-C6)alkyl or together, with the nitrogen carrying them, form a nitrogen-containing heterocycle),
• or linear or branched (C1-C6)alkenyl,
• R1 to R8, which may be identical or different, each represents
• hydrogen,
• linear or branched (C1-C6)alkyl optionally substituted by aryl, carboxy or linear or branched (C1-C6)alkoxycarbonyl,
• hydroxy,
• linear or branched (C1-C6)acyloxy,
• a group of formula NR12R13, wherein R12 and R13, which may be identical or different, each represents hydrogen or linear or branched (C1-C6)alkyl optionally substituted by a group of formula NR14R15, wherein R14 and R15, which may be identical or different, each represents linear or branched (C1-C6)alkyl or together, with the nitrogen atom carrying them, form a nitrogen-containing heterocycle,
• carboxy,
• linear or branched (C1-C6)alkoxy optionally substituted by aryl or by a group of formula NR14R15, wherein R14 and R15, which may be identical or different, each represents linear or branched (C1-C6)alkyl or together, with the nitrogen atom carrying them, form a nitrogen-containing heterocycle,
• linear or branched (C1-C6)alkenyloxy,
• or one of R1 to R8 forms, with another of R1 to R8 that is adjacent, a (C1-C2)alkylenedioxy group,
• X represents oxygen or NR16, wherein R16 represents hydrogen or linear or branched (C1-C6)alkyl, aryl or aryl-(C1-C6)alkyl in which the alkyl moiety may be linear or branched,
• R9 represents hydrogen, aryl, heteroaryl, or linear or branched (C1-C6)alkyl, wherein alkyl optionally contains one or more unsaturations and is optionally substituted by one or more identical or different groups selected from aryl, heteroaryl, (C3-C8)cycloalkyl, cyano and NR17R18 (wherein R17 and R18, which may be identical or different, each represents linear or branched (C1-C6)alkyl or together, with the nitrogen atom carrying them, form a nitrogen-containing heterocycle),
• isomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid or base,
• wherein isomers are to be understood as optical isomers and geometrical isomers of the C═NXR9,
• an aryl group is to be understood as:
• phenyl, biphenylyl or naphthyl, each of those groups optionally being substituted by one or more identical or different groups selected from halogen, linear or branched (C1-C6)alkyl (optionally substituted by one or more halogen), linear or branched (C1-C6)alkenyl (optionally substituted by phenyl), linear or branched (C1-C6)alkoxy (optionally substituted by phenyl), phenoxy, nitro, cyano, amino (optionally substituted by one or two linear or branched (C1-C6)alkyl) and (C1-C2)alkylenedioxy,
• a heteroaryl group is to be understood as an aromatic mono- or bi-cyclic group having from 5 to 12 ring members containing one, two or three hetero atoms selected from oxygen, nitrogen and sulphur, wherein the heteroaryl may optionally be substituted by one or more identical or different groups selected from halogen, linear or branched (C1-C6)-alkyl, hydroxy, linear or branched (C1-C6)alkoxy, linear or branched (C1-C6)polyhaloalkyl, and amino (optionally substituted by one or more linear or branched (C1-C6)alkyl),
• and a nitrogen-containing heterocycle is to be understood as a saturated monocyclic group having from 5 to 7 ring members containing one, two or three hetero atoms, one of those hetero atoms being a nitrogen atom, and the additional hetero atom or atoms optionally present being selected from the atoms oxygen, nitrogen and sulphur.