Phorboxazole derivatives for treating cancer
AssigneeParker Hughes Institute
InventorsFatih M. Uckun, Rama K. Narla, Craig Forsyth, Chi Sing Lee, Feryan Ahmed, Russel Drew Cink
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Abstract
Synthetic Phorboxazole A and derivatives thereof for the treatment of cancer, including inhibition of cancer cell growth, induction of apoptosis, and inhibition of metastises.
Claims11
A composition comprising an effective therapeutic amount of the compound of the formula:
- 16
- and a pharmaceutically acceptable carrier
A composition comprising an effective therapeutic amount of the compound of the formula:
- 17
- and a pharmaceutically acceptable carrier
A composition comprising a therapeutically effective dose of one or more of:
- 29-phorboxamide A, 31-methyl-phorboxylate, and 18-methyl-phorboxylate and a pharmaceutically acceptable carrier.
A composition comprising an effective therapeutic dose of synthetic phorboxazole A having the formula (I) and a pharmaceutically acceptable carrier.
A method for inducing apoptosis of cancer cells, comprising administering to the cancer cells an effective dose of synthetic phorboxazole A.
A method for treating cancer comprising administering to a patient an effective therapeutic amount of a compound selected from synthetic Phorboxazole A;
- 29-phorboxamide A;
- 31-methyl-phorboxylate;
- and 18-methyl-phorboxylate.
Dependencies are inferred from the claim text.