Carbocyclic hydrazino inhibitors of copper-containing amine oxidases

A method of inhibiting a copper-containing amine oxidase comprising contacting said amine oxidase with an inhibitory effective amount of a compound of the Formula I′

• 19
• or an isomer or a pharmaceutically acceptable solvate, hydrate, or salt thereof;
• wherein:
• R1 is hydrogen or (C1-C4)alkyl, aralkyl, (C2-C5)alkanoyl, aroyl or heteroaroyl;
• R2 is hydrogen, optionally substituted (C1-C4)alkyl, or optionally substituted aralkyl;
• R3-R5 and R10, which can be the same or different, are hydrogen, optionally substituted (C1-C4)alkyl, optionally substituted aralkyl, optionally substituted phenyl or optionally substituted heteroaryl;
• R3 and R10 are cis or trans arranged;
• R11 is hydrogen, (C1-C4)alkyl, (C2-C5)alkanoyl or aralkyl;
• R6-R9, which can be the same or different, are hydrogen, optionally substituted (C1-C4)alkyl, halogen, hydroxy, optionally substituted (C1-C4)alkoxy, optionally substituted aralkyloxy, or (C1-C4)alkylamino;
• n is 1, 2 or 3.

A method of treating an inflammatory disease or condition, a disease related to carbohydrate metabolism, a disease related to aberrations in adipocyte differentiation or function or smooth muscle cell function, or a vascular disease, comprising administering to an animal in need or such treatment or prevention an effective amount of a compound of Formula I′:

• 20
• or an isomer or a pharmaceutically acceptable solvate, hydrate, or salt thereof;
• wherein:
• R1 is hydrogen or (C1-C4)alkyl, aralkyl, (C2-C5)alkanoyl, aroyl or heteroaroyl;
• R2 is hydrogen, optionally substituted (C1-C4)alkyl, or optionally substituted aralkyl;
• R3-R5 and R10, which can be the same or different, are hydrogen, optionally substituted (C1-C4)alkyl, optionally substituted aralkyl, optionally substituted phenyl or optionally substituted heteroaryl;
• R3 and R10 are cis or trans arranged;
• R11 is hydrogen, (C1-C4)alkyl, (C2-C5)alkanoyl or aralkyl;
• R6-R9, which can be the same or different, are hydrogen, optionally substituted (C1-C4)alkyl, halogen, hydroxy, optionally substituted (C1-C4)alkoxy, optionally substituted aralkyloxy, or (C1-C4)alkylamino;
• n is 1, 2 or 3.