Pharmaceutical compositions containing thiazolidinedione derivatives and process for their preparation
AssigneeSmithKline Beecham Corporation
InventorsRobin Edwin Buckingham, Michael Urquhart
Life of this patent
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Abstract
A method for reducing post-ischaemic injury of the heart and/or improving the functional recovery of the heart following myocardial ischaemia which method comprises administration of an effective, non-toxic amount of a glucose uptake enhancer to a human or non-human mammal in need thereof
Claims11
A pharmaceutical composition, which composition comprises an effective non-toxic amount of a compound of formula (I):
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- or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein:
- A1 represents OH or —OSO2OH;
- R1 represents a hydrogen atom or a C1-6 alkyl group;
- and
- R2 and R3 each represent hydrogen or R2 and R3 together represent a bond, and a pharmaceutically acceptable carrier therefor.
A process for the preparation of a compound of formula (I), which process comprises reacting a compound of formula (II):
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- wherein R2 and R3 are as defined in relation to the compounds of formula (I) and L1 represents a leaving group with a compound of formula (III):
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- wherein R1 is as defined in relation to formula (I) and A1 represents A1 as defined in relation to formula (I) or a protected form thereof;
- and thereafter, if required, carrying out one or more of the following optional steps:
- (i) converting a compound of formula (I) into a further compound of formula (I);
- (ii) removing any necessary protecting group;
- (iii) preparing a pharmaceutically acceptable salt of the compound of formula (I) and/or a pharmaceutically acceptable solvate thereof.
A method for the treatment of Type 2 diabetes or conditions associated with Type 2 diabetes in a human or non-human mammal, which method comprises administering an effective non-toxic amount of a compound of formula (I), or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof and/or a pharmaceutically acceptable solvate thereof to a human or non-human mammal in need thereof.
Dependencies are inferred from the claim text.