Hydrohalide salts of an HIV protease inhibitor
OwnerFred J. Fleitz, Daniel E. Petrillo +4inventors
InventorsFred J. Fleitz, Daniel E. Petrillo, Yaling Wang, Russell R. Ferlita, David C. Dubost, Joseph D. Armstrong III
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Abstract
Pharmaceutically acceptable hydrochloride and hydrobromide salts of Compound A are disclosed, wherein Compound A is of formula: 1 Compound A and its hydrobromide and hydrochloride salts are HIV protease inhibitors useful for preventing or treating HIV infection, for delaying the onset of AIDS, and for treating AIDS. Pharmaceutical compositions employing the crystalline salts, and processes for making and using the crystalline salts are also disclosed.
Claims20
A hydrohalide salt of Compound A, wherein Compound A is of formula:
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- and the hydrohalide is hydrochloride or hydrobromide.
A Form I crystalline hydrochloride salt of Compound A, characterized by crystallographic d-spacings of 4.2, 4.9, and 5.7 angstroms;
- wherein Compound A is of formula:
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A Form II crystalline hydrochloride salt of Compound A, characterized by crystallographic d-spacings of 5.0, 6.4, and 15.7 angstroms;
- wherein Compound A is of formula:
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A crystalline hydrobromide salt of Compound A, characterized by crystallographic d-spacings of 3.8, 3.9, and 4.2 angstroms;
- wherein Compound A is of formula:
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Dependencies are inferred from the claim text.