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US 2003/0125331 A1Published application
Cyclohexenyl-ethyl-thiourea compounds and use
AssigneeParker Hughes Institute
InventorsFatih M. Uckun, Taracad K. Ventatachalam
Life of this patent
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Abstract
Novel CycloHexenyl-Ethyl-Thiourea (CHET) compounds as inhibitors of reverse transcriptase and effective agents for the treatment of HIV infection, including mutant, drug-sensitive, drug-resistant, and multi-drug resistant strains of HIV.
Claims8
A method for treating drug-resistant HIV in a subject comprising administering to said subject an effective amount of at least one compound of the formula
- 9
- wherein
- n is 0 to 6;
- R is H, halogen, (C1-C12) alkyl, (C1-C12) alkoxy, amino, cyano, nitro, or hydroxy;
- and
- R1 comprises cyclo(C3-C12) alkyl, cyclo(C3-C12) alkenyl, isothiazolyl, tetrazolyl, triazolyl, pyridyl, imidazolyl, phenyl, napthyl, benzoxazolyl, benzimidazolyl, thiazolyl, oxazolyl, benzothiazolyl, pyrazinyl, pyridazinyl, thiadiazolyl, benzotriazolyl, pyrolyl, indolyl, benzothienyl, thienyl, benzofuryl, quinolyl, isoquinolyl, or pyrazolyl;
- or a pharmaceutically acceptable addition salt thereof:
4 more elements
Dependencies are inferred from the claim text.