Use of selective potassium channel openers

A use of a compound of the general formula (I):

• 6
• wherein
• B represents >NR5 or >CR5R6, wherein R5 and R6 independently are hydrogen;
• hydroxy;
• C1-6-alkoxy;
• or C1-6-alkyl, C3-6-cycloalkyl, C2-6-alkenyl or C2-6-alkynyl optionally mono- or poly substituted with halogen;
• or R5 and R4 together represent one of the bonds in a double bond between the atoms 2 and 3 of formula (I);
• D represents —S(═O)2— or —S(═O)—;
• or
• D-B represents —S(═O)(R7)═N—
• wherein R7 is C1-6-alkyl;
• or aryl or heteroaryl optionally mono- or poly substituted with halogen, hydroxy, C1-6-alkoxy, aryloxy, arylalkoxy, nitro, amino, C1-6-monoalkyl- or dialkylamino, cyano, acyl, or C1-6-alkoxycarbonyl;
• R1 is hydrogen;
• hydroxy;
• C1-6-alkoxy;
• or C1-6-alkyl, C3-6-cycloalkyl, C2-6-alkenyl or C2-4-alkynyl optionally mono- or poly substituted with halogen and R4 is hydrogen;
• or R4 together with R5 represent one of the bonds in a double bond between the atoms 2 and 3 of formula (I);
• or R1 together with R4 represent one of the bonds in a double bond between the atoms 3 and 4 of formula (I);
• R2 is hydrogen;
• hydroxy;
• C1-6-alkoxy;
• or C1-6-alkyl, C3-6-cycloalkyl, C2-6-alkenyl or C2-6-alkynyl optionally mono- or poly substituted with halogen;
• R3 is R8;
• —OR8;
• —C(═X)R8;
• —NR8R9;
• bicycloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl optionally mono- or poly substituted with halogen, hydroxy, C1-6-alkoxy, aryloxy, arylalkoxy, nitro, amino, C1-6-monoalkyl- or dialkylamino, cyano, oxo, acyl or C1-6-alkoxycarbonyl;
• or aryl substituted with C1-6-alkyl;
• wherein R8 is hydrogen;
• C3-6-cycloalkyl or (C3-6-cycloalkyl)C1-6-alkyl, the C3-6-cycloalkyl group optionally being mono- or poly substituted with C1-6-alkyl, halogen, hydroxy or C1-6-alkoxy;
• a 3-6 membered saturated ring system comprising one or more nitrogen, oxygen or sulfur atoms;
• or straight or branched C1-18-alkyl optionally mono- or poly substituted with halogen, hydroxy, C1-6-alkoxy, C1-6-alkylthio, C3-6-cycloalkyl, aryl, aryloxy, arylalkoxy, nitro, amino, C1-6-monoalkyl- or dialkylamino, cyano, oxo, formyl, acyl, carboxy, C1-6-alkoxycarbonyl, or carbamoyl;
• X is O or S;
• R9 is hydrogen;
• C1-6alkyl;
• C2-4-alkenyl;
• C3-6-cycloalkyl optionally mono- or poly substituted with C1-6-alkyl, halogen, hydroxy or C1-6-alkoxy;
• or
• R8 and R9 together with the nitrogen atom form a 3-12 membered mono- or bicyclic system, in which one or more of the carbon atoms may be exchanged with nitrogen, oxygen or sulfur, each of these ring systems optionally being mono- or poly substituted with halogen, C1-6-alkyl, hydroxy, C1-6-alkoxy, C1-6alkoxy-C1-6-alkyl, nitro, amino, cyano, trifluoromethyl, C1-6-monoalkyl- or dialkylamino, oxo;
• or
• R3 is
• 7
• wherein n, m, p independently are 0, 1, 2, 3 and R10 is hydrogen;
• hydroxy;
• C1-6alkoxy;
• C3-6-cycloalkyl optionally mono- or poly substituted with C1-6-alkyl, halogen, hydroxy or C1-6-alkoxy;
• C1-6-alkyl, C2-4-alkenyl or C2-6-alkynyl optionally mono- or poly substituted with halogen;
• or
• R2 and R3 together with the nitrogen atom forms a 3-12 membered mono- or bicyclic system, in which one or more of the carbon atoms may be exchanged with nitrogen, oxygen or sulfur, each of these ring systems optionally being mono- or poly substituted with halogen, C1-6-alkyl, hydroxy, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, nitro, amino, cyano, trifluoromethyl, C1-6-monoalkyl- or dialkylamino or oxo;
• A together with carbon atoms 5 and 6 of formula (I) represents a 5 or 6 membered heterocyclic system comprising one or more nitrogen-, oxygen- or sulfur atoms, the heterocyclic systems optionally being mono- or poly substituted with halogen;
• C1-12-alkyl;
• C3-4-cycloalkyl;
• hydroxy;
• C1-6-alkoxy;
• C1-6-alkoxy-C1-6-alkyl;
• nitro;
• amino;
• cyano;
• cyanomethyl;
• perhalomethyl;
• C1-6-monoalkyl- or dialkylamino;
• sulfamoyl;
• C1-6-alkylthio;
• C1-6-alkylsulfonyl;
• C1-6-alkylsulfinyl;
• C1-6-alkylcarbonylamino;
• arylthio, arylsulfinyl, arylsulfonyl, the aryl group optionally being mono- or polysubstituted with C1-6-alkyl, halogen, hydroxy or C1-6-alkoxy;
• C1-6-alkoxycarbonyl;
• C1-6-alkoxycarbonyl-C1-6-alkyl;
• carbamyl;
• carbamyl-methyl;
• C1-6-monoalkyl- or dialkylaminocarbonyl;
• C1-6-monoalkyl- or dialkylaminothiocarbonyl;
• ureido;
• C1-6-monoalkyl- or dialkylaminocarbonylamino, thioureido;
• C1-6-monoalkyl- or dialkylaminothiocarbonyl-amino;
• C1-6-monoalkyl- or dialkylaminosulfonyl;
• carboxy;
• carboxy-C1-6-alkyl;
• acyl;
• aryl, arylalkyl, aryloxy, the aryl group optionally being mono- or polysubstituted with C1-6-alkyl, halogen, hydroxy or C1-6-alkoxy;
• (1,2,4-oxadiazol-5-yl)- or (1,2,4-oxadiazol-3-yl)-C1-6-alkyl the oxadiazolyl group optionally being substituted with C1-6-alkyl or C3-4-cycloalkyl;
• or a 5-6 membered nitrogen containing ring, optionally substituted with phenyl or C1-6-alkyl;
• or a pharmaceutically acceptable salt thereof, for the preparation of a pharmaceutical composition for the treatment or the prevention of diabetes and for the treatment of hyperinsulinaemia and hyperandrogenism in women with Polycystic Ovary Syndrome.