Substituted phenyl-piperazine derivatives, their preparation and use

A compound of general formula I

• 15
• wherein Z represents NH, NR′″, O or S;
• R′″ represents hydrogen, C1-6-alkyl;
• R7 and R8 independently represent hydrogen, halogen, C1-6-alkyl, C3-8-cycloalkyl, CN, CF3 or C1-6-alkoxy;
• or R7 and R8 together form a 5- or 6-membered aryl or heteroaryl fused to the benzene-ring;
• Y represents N, C or CH;
• the dotted line represents an optional bond;
• R6 and R6′ represent H or C1-6-alkyl;
• X represents —O— or —S— n is 2, 3, 4 or 5;
• m is 2 or 3;
• R1, R2, R3, R4 and R5 are independently selected from a group consisting of hydrogen, halogen, C1-6-alkyl, C1-6-alkenyl, C1-6-alkynyl, C3-8-cycloalkyl, aryl, hydroxy, hydroxy-C1-6-alkyl, C1-6-alkoxy, C3-8-cycloalkoxy, C1-6-alkylsulfanyl, acyl, NR9R10 wherein R9 and R10 independently represent hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl or aryl;
• or R9 and R10 together with the nitrogen to which they are attached form a 1-morpholinyl, 1-piperidinyl, 1-homopiperidinyl, 1-piperazinyl, 1-homopiperazinyl, 1-imidazolyl, 1-pyrrolyl, or pyrazolyl, all of which may be further substituted with C1-6-alkyl;
• or two adjacent substituents of R1-R5 together form a ring fused to the phenyl ring selected from the group consisting of
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• wherein W is O or S, and R′ and R″ are hydrogen or C1-6-alkyl:
• or a pharmaceutically acceptable acid addition salt or prodrug thereof