Compounds capable of binding with the cytoskeleton
OwnerEtienne-Emile Baulieu, Paul Robel +2inventors
InventorsEtienne-Emile Baulieu, Paul Robel, Esther Pellous, Kokhi Murakami
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Abstract
The invention concerns the use of steroids and non-toxic compounds, capable of crossing the blood brain barrier characterised in that they are capable of binding the same site as pregnenolone on proteins constituting or associated with elements of the cytoskeleton and of displacing the MAP-bound pregnenolone, and of influencing the assembling and stabilisation of microtubules The invention is particularly useful for treating the nervous system, for fighting against ageing of cells containing MAPs, and for treating cancers.
Claims12
Non-toxic compounds capable of passing through the blood-brain barrier, characterized in that they are capable of binding to the same site as pregnenolone on proteins constituting or associated with cytoskeletal elements and of displacing pregnenolone bound to MAP2, as well as having an effect on the assembly and the stablization of microtubules.
Dependencies are inferred from the claim text.