Substituted amino ketone compounds

compounds of the general formula I

• B—(CH—R1)n—C(=X2)—D (I)
• wherein
• n is 0 or 1,
• R1 stands for H, C1-C9 branched or straight chain alkyl, n-butan-2-yl, n-prop-2-yl or isobutyl, C2-C9 branched or straight chain alkenyl, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, heteroaryl or a side chain of a natural amino acid or derivatives thereof,
• X2 stands for O,NR6, N+(R7)2, or S,
• B is selected from the following groups:
• 23
• where X5 is H or an acyl or oxycarbonyl group including amino acids,
• R5 is H, C1-C9 branched or straight chain alkyl, C2-C9 branched or straight chain alkenyl, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, heteroaryl or a side chain of a natural amino acid or mimetics thereof, or a group of the formula —(CH)m—NH—C5H3N—Y where m is an integer of 2-4, —C5H3N—Y is a divalent pyridyl moiety and Y is a hydrogen atom, a halogen atom, a nitro group or a cyano group,
• Z is selected from H, pyridyl or optionally substituted phenyl, optionally substituted alkyl groups, alkoxy groups, halogens, nitro, cyano and carboxy groups,
• W is selected from H, pyridyl or optionally substituted phenyl, optionally substituted alkyl groups, alkoxy groups, halogens, nitro, cyano and carboxy groups,
• W1 is H or optionally substituted alkyl, alkoxy or optionally substituted phenyl, and
• Z1 is H, or optionally substituted alkyl,
• R3 and R4 are independently H, hydroxy, alkyl, alkoxy, aralkoxy, nitro, cyano or halogen,
• D is an optionally substituted compound of the formula
• 24
• which can be saturated, or can have one, two or three double bonds, wherein
• X8 to X11 are independently CH, N. N+(R7), or CR8, if unsaturated, or
• X8 to X11 are independently CH2, NH, NH+(R7), O. or S if saturated,
• X12 is CHA, NA, CH2, NH, NH+(R7), or CHR8, if saturated or
• X12is CA, NA+, CH, N, N+(R7), or CR8, if unsaturated and
• A is H or an isoster of a carboxylic acid, PO3R5R6, a tetrazole, an amide, an ester or an acid anhydride,
• R6, R7 R8 and R9 are independently selected from H, optionally substituted C1-C9 branched or straight chain alkyl, or optionally substituted C2-C9 branched or straight chain alkenyl, or optionally substituted C3-C8 cycloalkyl, or an optionally substituted C5-C7 cycloalkenyl, or an optionally substituted aryl residue.