Folic acid-polysaccharide complex, its preparation method and pharmaceutical composition containing the same as active component
AssigneeFudan University
InventorsWeiyue Lu, Min Liu, Jun Pan
Life of this patent
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Abstract
The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof, pharmaceutical compositions having said complex as active component and uses of said composition in therapy of tumors. The folic acid-polysaccharide complexs of the present invention have general formula of: (X)n—Y, wherein X is identical or different, and is selected from folic acid, derivatives of folic acid and other substances that can enter into cell via the pathway of folic acid receptor; Y is polysaccharide; n≧1.
Claims14
A folic acid-polysaccharide complex, characterizing in that it has the following general formula:
- (X)n—Y, wherein X is identical or different, and is selected from the group consisting of folic acid, or derivatives thereof, and other substances that can enter into cell via the pathway of folic acid receptor on the cell membrane;
- Y is polysaccharides other than arabinogalactan;
- n≧1.
A method for producing folic acid-polysaccharide complex, characterizing in that said method comprises:
- condensing components of folic acid and polysaccharides in the presence of alkali catalyst and dehydrating agent to obtain folic acid-polysaccharide complex.
Use of folic acid-polysaccharide complex in preparation of medicament for antineoplastics.
Dependencies are inferred from the claim text.