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US 2003/0125300 A1Published application
Method and composition for conjugating molecules to nucleic acids
AssigneeWhitehead Institute for Biomedical Research
InventorDavid H. Lee
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Abstract
Thiolester-activated amino acids; thiolester-activated nucleotides; polypeptide-oligonucleotide fusions comprising a polypeptide of interest and a thiolester-activated nucleotide; methods of producing the thiolester-activated nucleotides of the present invention; methods of producing polypeptide-oligonucleotide fusions of the present invention; and methods in which the polypeptide-oligonucleotide fusions are used, such as methods of delivering nucleic acid molecules into cells and cell lines.
Claims2
A thiolester-activated nucleotide of the formula:
- 3
- , wherein R is a hydrocarbon-containing group and X is a nucleophile.
Dependencies are inferred from the claim text.