Cancer therapy comprising deaminase enzyme inhibitors
OwnerStuart E. Lind, Catherine P. Barryinventors
Life of this patent
Estimating the term…
Abstract
The present invention provides materials and methods for the treatment of neoplastic disease states, especially cancers of cells/organs of epithelial origin. For example, the invention provides chemotherapeutic materials and methods for treatment comprising an inhibitor of at least one of the enzymes adenosine deaminase and AMP deaminase.
Claims25
A method of inducing cell death in tumor cells, comprising administering to a human subject a composition comprising a compound selected from the group consisting of adenosine deaminase inhibitors (ADAI), adenosine monophosphate deaminase inhibitors (AMPDAI), and pharmaceutically acceptable salts thereof, wherein the human subject has a tumor with elevated adenosine in the tumor cells or in extracellular fluid of the tumor, and wherein the composition is administered in an amount sufficient to induce cell death in cells of the tumor.
A method of inducing cell death in tumor cells, comprising:
- screening a human subject for elevated adenosine in a tumor or in extracellular fluid of a tumor, and
- administering to a human subject diagnosed with the tumor with the elevated adenosine a composition comprising a compound selected from the group consisting of adenosine deaminase inhibitors (ADAI), adenosine monophosphate deaminase inhibitors (AMPDAI), and pharmaceutically acceptable salts thereof, wherein the composition is administered in an amount sufficient to induce cell death in cells of the tumor.
A kit for treating a neoplastic disease state comprising a container holding a compound selected from the group consisting of adenosine deaminase inhibitors (ADAI), adenosine monophosphate deaminase inhibitors (AMPDAI), combinations thereof, and pharmaceutically acceptable salts thereof and a label attached to or packaged with the container, the label describing use of the compound for inducing cell death in tumors with elevated adenosine.
Dependencies are inferred from the claim text.