Therapeutically useful triethyleneglycol cholesteryl oligonucleotides
AssigneeBioniche Life Sciences Inc.
InventorsNigel C. Phillips, Mario C. Filion, Andrea C. Herrera Gayol
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Abstract
The present invention provides a composition comprising a 5′-OH, 3′-TEG cholesteryl synthetic sequence wherein the sequence is SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8. The present invention provides methods of using this composition for induction of response in a cell, including but not limited to inhibition of cellular proliferation, induction of cell cycle arrest, induction of caspase activation, cleavage of poly(ADP-ribose) polymerase, induction of apoptosis or modulation of extracellular matrix-cell interactions, or combinations thereof, in cancer cells or synovial cells, and methods of using this composition for treating disease.
Claims31
A composition comprising a 5′-OH, 3′-TEG cholesteryl synthetic sequence, wherein the sequence is SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7 or SEQ ID NO:8.
Dependencies are inferred from the claim text.