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US 2003/0125288 A1Published application
PI3K - regulatory subunit homology
OwnerIdit Azar, Zurit Levine +2inventors
InventorsIdit Azar, Zurit Levine, Jeanne Bernstein, Kinneret Savitzky
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Abstract
The invention concerns novel nucleic acid and amino acid sequences which are homologs of the PI3K-regulatory subunits. The invention also concerns pharmaceutical compositions containing these sequences as well as methods of detection using the sequences.
Claims39
An isolated nucleic acid sequence selected from:
- (i) the nucleic acid sequence depicted in SEQ ID NO:1 or SEQ ID NO:2;
- (ii) nucleic acid sequences having at least 70% identity with the sequence of (i) over the entire sequence.
A method for identifying candidate compounds capable of binding to the PI-rsh product and modulating its activity the method comprising:
- (i) providing a protein or polypeptide comprising an amino acid sequence substantially as depicted in SEQ ID NO:3, or a fragment of such a sequence;
- (ii) comparing the physiological effect of the PI-rsh product in the absence and presence of said candidate compound and selecting those compounds which show a significant effect on said physiological activity.
A method for identiing candidate compounds capable of binding to the PI-rsh product and modulating its activity the method comprising:
- (i) providing a protein or polypeptide comprising an amino acid sequence substantially as depicted in SEQ ID NO:4, or a fragment of such a sequence;
- (ii) comparing the physiological effect of the PI-rsh product in the absence and presence of said candidate compound and selecting those compounds which show a significant effect on said physiological activity.
Dependencies are inferred from the claim text.