Antisense oligonucleotides and methods to induce tumor cell death
AssigneeHybridon, Inc.
InventorsEkambar R. Kandimalla, Sudhir Agrawal, Sai Latha Shankar, Sridhar Mani, Bridget Shafit-Zagardo
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Abstract
This invention relates to the inhibition and down-regulation of survivin expression. The invention provides methods and antisense oligonucleotides for inhibiting or down-regulating survivin expression in cells and promoting apoptosis and cell necrosis.
Claims28
A synthetic oligonucleotide complementary to a nucleic acid encoding survivin protein, the synthetic oligonucleotide having SEQ ID NO:
- 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11.
A synthetic oligonucleotide complementary to a nucleic acid encoding survivin protein, the synthetic oligonucleotide having a nucleic acid sequence that is at least 85% identical to the nucleic acid sequence of SEQ ID NO:
- 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11.
Dependencies are inferred from the claim text.