Human mater proteins
AssigneeSchering Corporation
InventorsBertram Weiss, Monika Lessl, Michaele Peters-Kottig, Georg Beckmann
Life of this patent
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Abstract
Two human MATER proteins as well as their use for fertility disorders, therapy and diagnosis are described.
Claims26
Nucleic acid that comprises
- a. The nucleotide sequence that is shown in Seq ID NO 1 or Seq ID NO 3,
- b. A nucleotide sequence that corresponds to a sequence from a. within the scope of the degeneration of the genetic code or
- c. A nucleotide sequence that hybridizes with the sequences from a. or b. under stringent conditions with the function of a human MATER protein.
Nucleic acid that codes for a polypeptide with the amino acid sequence that is shown in Seq ID NO 2 or Seq ID NO 4.
Polypeptide that comprises the amino acid sequence or portions thereof shown in Seq ID NO 2 or in Seq ID NO 4.
Diagnostic process for determining autoimmune-antibodies against MATER in bodily samples (tissue, liquids).
Diagnostic process for determining the amount of Mater protein or Mater mRNA in ovocytes.
DNA chip, characterized in that at least one oligonucleotide is immobilized, which corresponds to the complete cDNA sequence or a partial sequence or a complementary sequence to the one described in Seq ID NO 1 or Seq ID NO 3.
Use of modulators of Mater expression for treating fertility disorders that are produced by endometriosis.
Dependencies are inferred from the claim text.