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AssigneesMedical University of South Carolina, The Penn State Research Foundation, a Pennsylvania corporation
InventorsJames S. Norris, Michael G. Schmidt, Joseph W. Dolan, Steven D. London, Harold D. May, Gary A. Clawson
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The invention provides compositions comprising the tissue specific and target RNA-specific ribozyme(s) in either a viral delivery system or a biologic liposome preparation, wherein the viral delivery system or a biologic liposome comprises a pathogen-specific promotor upstream from a sequence encoding a triple ribozyme comprising a) a 5′ autocatalytically cleaving ribozyme sequence, b) a catalytic ribozyme comprising a target RNA-specific binding site and c) a 3′ autocatalytically cleaving ribozyme sequence. The invention also provides methods of treating and/or preventing bacterial infections by administering the compositions of the invention.
A virion, modified to be non-replicative and comprising non-viral DNA.
A liposome comprising a nucleic acid comprising a pathogen-specific promoter upstream from a sequence encoding a triple ribozyme comprising a) a 5′ autocatalytically cleaving ribozyme sequence, b) a catalytic ribozyme comprising a target RNA-specific binding site and c) a 3′ autocatalytically cleaving ribozyme sequence.
A nucleic acid comprising a pathogen-specific promoter upstream from a sequence encoding a triple ribozyme comprising a) a 5′ autocatalytically cleaving ribozyme sequence, b) a catalytic ribozyme comprising a target RNA-specific binding site and c) a 3′ autocatalytically cleaving ribozyme sequence.
The nucleic acid of any of claims 7, 8, 9, 10, 12, 13 or 14, wherein at least one triple ribozyme is targeted to the rpoA transcript of the pathogen.
The nucleic acid of any of claims 7, 8, 9, 10, 11, 13 or 14 wherein at least one triple ribozyme is targeted to the seca transcript of the pathogen.
The nucleic acid of any of claims 7, 8, 9, 10, 11, 12 or 14, wherein at least one triple ribozyme is directed to the dnaG transcript of the pathogen.
Dependencies are inferred from the claim text.