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OwnerDe-Chu C. Tang, Donald H. Marks +3inventors
InventorsDe-Chu C. Tang, Donald H. Marks, David T. Curiel, Zhongkai Shi, Kent Rigby van Kampen
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The present invention relates to techniques of skin-targeted non-invasive gene delivery to elicit immune responses and uses thereof. The invention further relates to methods of non-invasive genetic immunization in an animal and/or methods of inducing a systemic immune or therapeutic response in an animal following topical application of vectors, products therefrom and uses for the methods and products therefrom. The methods can include contacting skin of the animal with a vector in an amount effective to induce the systemic immune or therapeutic response in the animal as well as such a method further including disposing the vector in and/or on the delivery device. The vector can be gram negative bacteria, preferably Salmonella and most preferably Salmonella typhimurium.
A method of non-invasive genetic immunization in an animal and/or a method of inducing a systemic immune response or systemic therapeutic response to a gene product, in an animal, comprising contacting skin of the animal with a bacterial vector that contains and expresses a nucleic acid molecule encoding the gene product, in an amount effective to induce the response.
Dependencies are inferred from the claim text.