Antisense modulation of activating transcription factor 3 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrenda F. Baker, Kenneth Dobie
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of activating transcription factor 3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding activating transcription factor 3. Methods of using these compounds for modulation of activating transcription factor 3 expression and for treatment of diseases associated with expression of activating transcription factor 3 are provided.
Claims20
A compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding activating transcription factor 3, wherein said compound specifically hybridizes with said nucleic acid molecule encoding activating transcription factor 3 and inhibits the expression of activating transcription factor 3.
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding activating transcription factor 3.
Dependencies are inferred from the claim text.