Antisense modulation of hematopoietic cell protein tyrosine kinase expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsAlexander H. Borchers, Kenneth W. Dobie
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of hematopoietic cell protein tyrosine kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding hematopoietic cell protein tyrosine kinase. Methods of using these compounds for modulation of hematopoietic cell protein tyrosine kinase expression and for treatment of diseases associated with expression of hematopoietic cell protein tyrosine kinase are provided.
Claims20
A compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding hematopoietic cell protein tyrosine kinase, wherein said compound specifically hybridizes with said nucleic acid molecule encoding hematopoietic cell protein tyrosine kinase and inhibits the expression of hematopoietic cell protein tyrosine kinase.
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding hematopoietic cell protein tyrosine kinase.
Dependencies are inferred from the claim text.