Antisense modulation of toll-like receptor 4 expression
OwnerJames G. Karras, Erich Kollerinventors
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of Toll-like receptor 4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Toll-like receptor 4. Methods of using these compounds for modulation of Toll-like receptor 4 expression and for treatment of diseases associated with expression of Toll-like receptor 4 are provided.
Claims20
A compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding Toll-like receptor 4, wherein said compound specifically hybridizes with said nucleic acid molecule encoding Toll-like receptor 4 and inhibits the expression of Toll-like receptor 4.
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding Toll-like receptor 4.
Dependencies are inferred from the claim text.