Antisense modulation of vitamin D nuclear receptor expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrenda F. Baker, Kenneth Dobie, Mark P. Roach
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of vitamin D nuclear receptor. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding vitamin D nuclear receptor. Methods are provided for using these compounds for modulation of vitamin D nuclear receptor expression, including examples of modulation of specific variants of vitamin D nuclear receptor relative to other variants. Methods for treatment of diseases associated with expression of vitamin D nuclear receptor are provided.
Claims20
A compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding vitamin D nuclear receptor, wherein said compound specifically hybridizes with said nucleic acid molecule encoding vitamin D nuclear receptor and inhibits the expression of vitamin D nuclear receptor.
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding vitamin D nuclear receptor.
Dependencies are inferred from the claim text.