Anti-estrogen receptor agents for chemotherapy
OwnerMien-Chie Hung, Yiu-Keung Lau +1inventors
InventorsMien-Chie Hung, Yiu-Keung Lau, Yong Wen
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Abstract
Methods and compositions regarding the prevention of ER-positive cancer and the treatment of ER-positive HER-2/neu-negative breast cancer are disclosed. Compositions exhibiting both tyrosine kinase inhibitor activity and anti-estrogen receptor activity are useful in the cancer treatment.
Claims36
A method of preventing development or proliferation of one or more estrogen receptor positive cancer cells in an individual comprising administering to the individual a composition having anti-estrogen receptor activity.
A method of treating an estrogen receptor positive and HER-2/neu negative breast cancer cell comprising contacting the cell with a composition comprising tyrosine kinase inhibitor activity and anti-estrogen receptor activity.
A method of screening for a compound comprising tyrosine kinase inhibitor activity and anti-estrogen receptor activity, comprising:
- contacting an estrogen receptor positive and HER-2/neu negative breast cancer cell with a candidate substance;
- and
- assaying the candidate substance for tyrosine kinase inhibitor activity and anti-estrogen receptor activity in said cell.
Dependencies are inferred from the claim text.