Bone polypeptide-1
OwnerChristian Lanctot, Patrick Salois +1inventors
InventorsChristian Lanctot, Patrick Salois, Pierre Moffatt
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Abstract
The present invention relates to a bone polypeptide, particularly bone polypeptide-1 and nucleic acid molecules encoding the same. The present invention provides the human primary sequence of bone polypeptide-1 as well as sequences of vertebrate homologs. The invention also provides cell lines engineered to express the cDNA, antibodies to detect its translation products, and recombinant adenoviruses to deliver an expressible cDNA into a host. Bone polypeptide-1 can be utilized to treat diseases affecting renal and bone functions.
Claims29
An isolated nucleic acid encoding bone polypeptide-1
- wherein said bone polypeptide-1 comprises a polypeptide sequence selected from the group consisting of SEQ ID NO:9, SEQ ID NO:10;
- SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13 and SEQ ID NO:14.
An isolated nucleic acid wherein said nucleic acid hybridizes under high stringency conditions to the full length nucleic acid sequence of a nucleic acid selected from the group consisting of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:
- 6 and SEQ ID NO:7 or the complements thereof wherein said high stringency conditions includes hybrizing in 0.15 M NaCl at 72° C. for about 15 minutes and washing said hybridized DNA in 0.2×SSC at 65° C. for 15 minutes.
An isolated or recombinant bone polypeptide-1 wherein said bone polypeptide-1 comprises the amino acid sequence of SEQ ID NO:
- 9.
An isolated or recombinant bone polypeptide-1 fragment wherein said bone polypeptide-1 fragment comprises one or more peptides selected from the group consisting of SEQ ID NO:20, SEQ ID NO:
- 21, SEQ ID NO:22, SEQ ID NO:22;
- SEQ ID NO:23, SEQ ID NO:24 and SEQ ID NO:25.
An antibody that binds to an epitope in the polypeptide encoded by the nucleic acid of SEQ ID NO:2.
Dependencies are inferred from the claim text.