Method of inhibiting smooth muscle proliferation
AssigneeDuke University
InventorsWalter J. Koch, Jeffrey H. Lawson
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Abstract
The present invention relates, in general, to vascular smooth muscle proliferation and, in particular, to a method of inhibiting arterial and venous smooth muscle proliferation resulting, for example, from arterial injury, vein grafting or shunt implantation. The invention also relates to an expression construct encoding a Gβγ inhibitor suitable for use in such a method.
Claims15
A method of inhibiting proliferation of vascular smooth muscle cells at the venous outflow tract of an arteriovenous shunt or fistula comprising introducing into said cells an inhibitor of Gβγ-mediated processes in an amount and under conditions such that said inhibition of vascular smooth muscle cell proliferation is effected.
A method of manufacturing a stent or shunt comprising bonding to, or incorporating into, a stent or shunt an agent that inhibits proliferation of cells at risk of proliferation upon implantation into a patient of said stent or shunt, said agent being an inhibitor of Gβγ-mediated processes.
Dependencies are inferred from the claim text.