Novel protein, process for producing the same and use therof
OwnerYoshio Taniyama, Shunbun Kita +1inventors
InventorsYoshio Taniyama, Shunbun Kita, Tomoko Satomi nee Tomoko Komiyama
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Abstract
The present invention relates to a novel SSD(sterol-sensing domain)-containing protein derived from human liver, human testis and human brain, or a salt thereof, and a DNA encoding the same. Studies on the tissue-specificity of the protein expression, the expression change depending the intracellular cholesterol level, production of the transformant, and the site-specific expression in brain regions of a patient with Alzheimer's disease are disclosed.
Claims51
A protein or salt thereof, comprising the same or substantially the same amino acid sequence as that shown by SEQ ID NO:
- 16.
A protein or salt thereof, comprising the same or substantially the same amino acid sequence as that shown by SEQ ID NO:
- 8, but not comprising the amino acid sequence shown by SEQ ID NO. 38.
A prophylactic and/or therapeutic agent for diabetes mellitus, obesity, cancer, arterial sclerosis, hyperlipidemia, neurodegenerative diseases or neuropathy, comprising a compound or salt thereof having an action on an SSD-containing protein to manifest the regulation of intracellular cholesterol transport.
A method of preventing and treating diabetes mellitus, obesity, cancer, arterial sclerosis, hyperlipidemia, neurodegenerative diseases or neuropathy, comprising administering to a mammal an effective amount of a compound or salt thereof having an action on an SSD-containing protein to manifest the regulation of intracellular cholesterol transport.
Use of a compound or salt thereof having an action on an SSD-containing protein to manifest the regulation of intracellular cholesterol transport, for producing a prophylactic and/or therapeutic agent for diabetes mellitus, obesity, cancer, arterial sclerosis, hyperlipidemia, neurodegenerative diseases or neuropathy.
Dependencies are inferred from the claim text.