Therapeutic uses of LNA-modified oligonucleotides in infectious diseases
OwnerMargit Wissenbach, Troels Koch +2inventors
InventorsMargit Wissenbach, Troels Koch, Henrik Orum, Bo Hansen
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Abstract
The invention relates to therapeutic applications of LNA-modified oligonucleotides. In particular, the invention provides methods for treatment of infectious diseases and disorders caused by viruses, bacteria, protozoa or fungi. Preferably, administration of an LNA-modified oligonucleotide modulates expression of a targeted gene associated with the replication or infectivity of a virus, virulence genes, host immune modulating genes and the like. That is, preferred use of LNA-modified oligonucleotide provides an antisense-type therapy with selective modulation of gene expression of predetermined targets.
Claims57
A method of inhibiting propagation of an infectious agent associated with an infectious disease, comprising;
- contacting the infectious agent with an oligonucleotide that comprises one or more LNA units;
- wherein contacting of the LNA oligonucleotide to the infectious agent modulates expression of a gene of the infectious agent.
A method of modulating expression of a gene from an infectious agent associated with an infectious disease, comprising;
- contacting an oligonucleotide sequence of an infectious agent with a complementary oligonucleotide sequence that comprises one or more LNA units;
- whereby contacting of the LNA oligonucleotide sequence to the infectious agent modulates expression of a gene coding for the infectious agent.
A method of treating a mammal suffering from or susceptible to an infectious disease or disorder, comprising:
- administering to the mammal a therapeutically effective amount of an oligonucleotide that comprises one or more LNA units.
The method of claim 19 wherein the infectious disease is caused by or associated with a virus, bacteria, protozoa or fungi.
The method of claim 19 or 20 wherein the infectious agent is present in a lung, heart, liver, stomach, intestine, bowel, prostate, brain, spinal cord, sinuses, urinary tract or ovaries of the mammal.
A method for treating cells comprising an infectious agent, comprising:
- administering to the cells an oligonucleotide sequence that comprises one or more LNA units, the cells comprising an oligonucleotide sequence of an infectious agent.
Use of an LNA oligonucleotide for the preparation of a medicament for the preparation of an agent for the treatment of a bacterial, protozoa or fungi infection.
A pharmaceutical composition comprising an LNA oligonucleotide packaged together with written instructions for use of the oligonucleotide for the treatment of a disease or disorder associated with a bacterial, protozoa or fungi infection.
Dependencies are inferred from the claim text.