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AssigneeAdvenced Inhalation Research, Inc.
InventorsJennifer L. Schmitke, Donghao Chen, Richard P. Batycky, David A. Edwards
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The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.
A formulation having particles comprising, by weight, 60% DPPC, 30% insulin and 10% sodium citrate.
A formulation having particles comprising, by weight, 40% DPPC, 50% insulin and 10% sodium citrate.
A formulation having particles comprising, by weight, 40% to 60% DPPC, 30% to 50% insulin and 10% sodium citrate.
A formulation having particles comprising, by weight, 80% DPPC, 10% insulin and 10% sodium citrate.
A formulation having particles comprising, by weight, 75% DPPC, 15% insulin and 10% sodium citrate.
A formulation having particles comprising, by weight, 75% to 80% DPPC, 10% to 15% insulin and 10% sodium citrate.
A method for treating a human patient in need of insulin comprising administering pulmonarily to the respiratory tract of a patient in need of treatment, an effective amount of particles comprising by weight, 60% DPPC, 30% insulin and 10% sodium citrate, wherein release of the insulin is rapid.
A method for treating a human patient in need of insulin comprising administering pulmonarily to the respiratory tract of a patient in need of treatment, an effective amount of particles comprising by weight, 40% DPPC, 50% insulin and 10% sodium citrate, wherein release of the insulin is rapid.
A method for treating a human patient in need of insulin comprising administering pulmonarily to the respiratory tract of a patient in need of treatment, an effective amount of particles comprising by weight, 40% to 60% DPPC, 30% to 50% insulin and 10% sodium citrate, wherein release of the insulin is rapid.
A method for treating a human patient in need of insulin comprising administering pulmonarily to the respiratory tract of a patient in need of treatment, an effective amount of particles comprising by weight, 80% DPPC, 10% insulin and 10% sodium citrate, wherein release of the insulin is rapid.
A method for treating a human patient in need of insulin comprising administering pulmonarily to the respiratory tract of a patient in need of treatment, an effective amount of particles comprising by weight, 75% DPPC, 15% insulin and 10% sodium citrate, wherein release of the insulin is rapid.
A method for treating a human patient in need of insulin comprising administering pulmonarily to the respiratory tract of a patient in need of treatment, an effective amount of particles comprising by weight, 75% to 80% DPPC, 10% to 15% insulin and 10% sodium citrate, wherein release of the insulin is rapid.
A method of delivering an effective amount of insulin to the pulmonary system, comprising:
A method of delivering an effective amount of insulin to the pulmonary system, comprising:
A method of delivering an effective amount of insulin to the pulmonary system, comprising:
A method of delivering an effective amount of insulin to the pulmonary system, comprising:
A method of delivering an effective amount of insulin to the pulmonary system, comprising:
A method of delivering an effective amount of insulin to the pulmonary system, comprising:
A kit for administration of insulin comprising two or more receptacles, wherein said receptacles comprise unit dosages selected from the group consisting of
A formulation having particles comprising, by weight, 60% DPPC, 30% insulin and 10% sodium citrate, wherein the method of preparing said formulation comprises
A kit comprising at least two receptacles each receptacle containing a different amount of dry powder insulin suitable for inhalation.
Dependencies are inferred from the claim text.