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OwnerBrian Maurice John Foxwellinventor
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The present invention relates to a method of treating a condition comprising administering a pharmaceutically effective amount of an inhibitor of the Tec family of protein tyrosine kinases (PTKs). The condition is typically associated with cytokine production. Conditions addressed by the invention include sepsis, septic shock, inflammation, rheumatoid arthritis and Crohn's disease. In one embodiment, the condition is induced by zymosan. The invention also provides the use of an inhibitor of a member or members of the Tec family of PTKs in the manufacture of a medicament for use in the treatment of a condition associated with cytokine production and methods for identifying an inhibitor of a member or members of the Tec family of PTKs which is also suitable for use in the treatment of a condition associated with stimulus-induced cytokine production.
A method of treating a condition associated with cytokine production, wherein said condition is rheumatoid arthritis or a condition resulting from an infection, in a mammal comprising administering a pharmaceutically effective amount of an inhibitor of a member of the Tec family of protein tyrosine kinases (PTKs).
Use of an inhibitor of a member or members of the Tec family of PTKs in the manufacture of a medicament for the treatment of a condition associated with cytokine production, wherein said condition is rheumatoid arthritis or a condition resulting from an infection.
A method or use according to any one of the preceding claims wherein the condition is sepsis.
A method or use according to any one of the preceding claims wherein the condition is induced by a Toll Related Receptor (TRR) ligand.
A method or use according to any one of the preceding claims wherein the condition is induced by lipopolysaccharide (LPS).
A method or use according to any one of the preceding claims wherein the condition is induced by zymosan.
A method or use according to any one of the preceding claims wherein the inhibitor is specific for a member or members of the Tec family of PTKs.
A method or use according to any one of the preceding claims wherein the member of the Tec family of PTKs is Bruton's tyrosine kinase (Btk).
A method or use according to any one of the preceding claims wherein the inhibitor is a chemical inhibitor.
A method for identifying an inhibitor of a member or members of the Tec family of PTKs which inhibitor is suitable for use in the treatment of a condition associated with cytokine production wherein said condition is rheumatoid arthritis or a condition resulting from an infection, the method comprising:
Use of an inhibitor of a member or members of the Tec family of PTKs to study the inhibition of sepsis and/or septic shock caused by a TRR ligand, in vitro.
Dependencies are inferred from the claim text.