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AssigneeCuris, Inc.
InventorsCharles M. Cohen, Marc F. Charette, Thangavel Kuberasampath, David C. Rueger, Hermann Oppermann, Roy H.L. Pang, Engin Ozkaynak, John E. Smart
Estimating the term…
Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.
A method for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, the method comprising the step of:
A method for limiting the proliferation of an epithelial cell population in a mammal, the method comprising the step of providing a therapeutically effective concentration of a morphogen to a proliferating epithelial cell population in a mammal, said concentration being sufficient to inhibit the proliferation of said cells.
A method of treating a gastrointestinal tract ulcerative disease in a mammal, the method comprising the step of providing a therapeutically effective concentration of a morphogen to the ulcerated tissue of the gastrointestinal tract, said concentration being sufficient to repair said tissue.
A cancer treatment method comprising the steps of:
A method for enhancing the efficacy of cancer therapeutic treatment, the method comprising the step of administering a therapeutic concentration of a morphogen or morphogen-stimulating agent to the patient.
A therapeutic composition for treating ulcerations of the gastrointestinal tract comprising a therapeutic concentration of a morphogen or morphogen-stimulating agent in admixture with a biocompatible compound capable of coating the gastrointestinal tract luminal lining.
A therapeutic composition for treating ulcerations of the gastrointestinal tract comprising a therapeutic concentration of a morphogen or morphogen-stimulating agent in admixture with a biocompatible symptom-alleviating cofactor.
A composition useful as part of a cancer therapy comprising a therapeutic concentration of a morphogen or morphogen-stimulating agent in admixture with a cancer cell cytotoxin.
An oral rinse for treating oral mucositis comprising a therapeutically effective concentration of a morphogen or morphogen-stimulating agent.
A therapeutic composition for treating ulcerations of the gastrointestinal tract comprising a therapeutically effective concentration of a morphogen dispersed in a controlled release delivery vehicle.
A therapeutic composition for treating ulcerations of the gastrointestinal tract comprising a therapeutically effective concentration of a morphogen dispersed in a tissue adhesive composition.
Dependencies are inferred from the claim text.